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Proinflammatory Event of Ozonized Olive Oil in Mice

Publication Cover

Ozone: Science & Engineering

The Journal of the International Ozone Association

Volume 31, 2009 - Issue 3

 
Authors: Hiromi Kataoka , Masanori Semma , Humitoshi Sakazaki , Katsuhiko Nakamuro , Tadashi Yamamoto , Seiichi Hirota , show all

Pages 238-246 | Received 21 May 2008, Accepted 02 Feb 2009, Published online: 27 May 2009

 

ABSTRACT:

Ozonized olive oil inhibited the swelling reaction of 2, 4-dinitrofluorobenzene-induced mouse-contact hypersensitivity, which is a model for chronic skin diseases involved in the initiation and propagation of several inflammatory processes, mainly due to type IV hypersensitivity. On the other hand, ozonized olive oil itself stimulated the development of inflammatory responses, such as vasodilation, swelling and epidermal hyperplasia. When repeatedly applied to the skin, ozonized olive oil caused hair loss at the site and contact hypersensitivity. These findings identify a new biological function for ozonized olive oil and indicate the risk of adverse effects with repeated application.

 

Purchase paper here:

https://www.tandfonline.com/doi/full/10.1080/01919512.2017.1322490

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Additional information on Ozonated Olive Oil can be found HERE