Pages 238-246 | Received 21 May 2008, Accepted 02 Feb 2009, Published online: 27 May 2009
Ozonized olive oil inhibited the swelling reaction of 2, 4-dinitrofluorobenzene-induced mouse-contact hypersensitivity, which is a model for chronic skin diseases involved in the initiation and propagation of several inflammatory processes, mainly due to type IV hypersensitivity. On the other hand, ozonized olive oil itself stimulated the development of inflammatory responses, such as vasodilation, swelling and epidermal hyperplasia. When repeatedly applied to the skin, ozonized olive oil caused hair loss at the site and contact hypersensitivity. These findings identify a new biological function for ozonized olive oil and indicate the risk of adverse effects with repeated application.