Ozonated Olive Oil Enhances the Growth of Granulation Tissue in a Mouse Model of Pressure Ulcer

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Ozone: Science & Engineering

The Journal of the International Ozone Association

Volume 29, 2007 - Issue 6

Authors: F. Sakazaki , H. Kataoka , T. Okuno , H. Ueno , M. Semma , A. Ichikawa & show all

Pages 503-507 | Received 31 Jan 2007, Accepted 21 Jun 2007, Published online: 07 Dec 2007


The curative effect of ozonated olive oil was evaluated using mouse models of cut wounds and pressure ulcers (decubitus or bedsores). Although ozonated olive oil did not significantly accelerate or decelerate wound contraction in either model, some histological modifications were observed. Ozonated olive oil induced blood coagulation in the hypodermis and cell infiltration in the dermis 1 day after its application. Moreover, it enhanced the formation of granulation tissue 10 days after application. These results indicate that ozonated olive oil promotes granulation tissue formation and is effective in the healing of wounds and pressure ulcers.


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